Full Name
Morgane PRIME Toulouse
Research center
Inflammatory Diseases of the Central Nervous System: Mechanisms and Therapies
Research team
Toulouse NeuroImaging Center (UMR 1214, INSERM/Toulouse III University)
Title
Functional characterization of microglia in Parkinson's disease - roles of Foxo3
Project Summary
Parkinson's disease (PD) is characterized by chronic inflammation. A central role for microglia, the brain's resident cells, has been demonstrated in the establishment of this neuroinflammation. Foxo3-deficient mice are less sensitive to MPTP intoxication (the neurotoxin that induces the pathology). We are therefore studying the influence of Foxo3 on microglial functions in neuroinflammatory processes during PD.
