First name

Pascal

Last name

FOSSAT

Research center

Professor, University of Bordeaux/ CNRS

Research team

Monoamine Parkinson and Pain. Institute of neurodegenerative diseases.
Pascal FOSSAT

Title

Pain in Parkinson's disease: a consequence of motor disorders or a disorder in its own right?

Project Summary

Parkinson's disease is well known for its motor triad of akinesia, resting tremor and postural rigidity, but it is also accompanied by non-motor symptoms that increase the disability of sufferers. Our research team is particularly interested in the role of monoaminergic systems in the pathophysiology of the non-motor symptoms of Parkinson's disease. We are focusing in particular on the pain associated with Parkinson's disease, which is a major problem and for which there is no satisfactory treatment to relieve patients. Our aim is to gain a better understanding of the plasticity that takes place in the dorsal horn of the spinal cord, but also in the basal ganglia, so as to enable the emergence of new, effective therapeutic approaches.